Predicting and affecting response to cancer therapy based on pathway-level biomarkers

Identifying robust, patient-specific, and predictive biomarkers presents a major obstacle in precision oncology. To optimize patient-specific therapeutic strategies, here we couple pathway knowledge with large-scale drug sensitivity, RNAi, and CRISPR-Cas9 screening data from 460 cell lines. Pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Ben-Hamo, Rotem, Jacob Berger, Adi, Gavert, Nancy, Miller, Mendy, Pines, Guy, Oren, Roni, Pikarsky, Eli, Benes, Cyril H., Neuman, Tzahi, Zwang, Yaara, Efroni, Sol, Getz, Gad, Straussman, Ravid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335104/
https://www.ncbi.nlm.nih.gov/pubmed/32620799
http://dx.doi.org/10.1038/s41467-020-17090-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335104/
https://www.ncbi.nlm.nih.gov/pubmed/32620799
http://dx.doi.org/10.1038/s41467-020-17090-y

Ejemplares similares