Cargando…

Predicting and affecting response to cancer therapy based on pathway-level biomarkers

Identifying robust, patient-specific, and predictive biomarkers presents a major obstacle in precision oncology. To optimize patient-specific therapeutic strategies, here we couple pathway knowledge with large-scale drug sensitivity, RNAi, and CRISPR-Cas9 screening data from 460 cell lines. Pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ben-Hamo, Rotem, Jacob Berger, Adi, Gavert, Nancy, Miller, Mendy, Pines, Guy, Oren, Roni, Pikarsky, Eli, Benes, Cyril H., Neuman, Tzahi, Zwang, Yaara, Efroni, Sol, Getz, Gad, Straussman, Ravid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335104/ https://www.ncbi.nlm.nih.gov/pubmed/32620799 http://dx.doi.org/10.1038/s41467-020-17090-y

Ejemplares similares

Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression
por: Ben-Hamo, Rotem, et al.
Publicado: (2011)

Biomarker robustness reveals the PDGF network as driving disease outcome in ovarian cancer patients in multiple studies
por: Ben-Hamo, Rotem, et al.
Publicado: (2012)

The whole-organism heavy chain B cell repertoire from Zebrafish self-organizes into distinct network features
por: Ben-Hamo, Rotem, et al.
Publicado: (2011)

Correction: Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression
por: Ben-Hamo, Rotem, et al.
Publicado: (2012)

MicroRNA-Gene Association As a Prognostic Biomarker in Cancer Exposes Disease Mechanisms
por: Ben-Hamo, Rotem, et al.
Publicado: (2013)

MicroRNA regulation of molecular pathways as a generic mechanism and as a core disease phenotype
por: Ben-Hamo, Rotem, et al.
Publicado: (2015)

hsa-miR-9 controls the mobility behavior of glioblastoma cells via regulation of MAPK14 signaling elements
por: Ben-Hamo, Rotem, et al.
Publicado: (2015)

SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade
por: Cashman, Rivki, et al.
Publicado: (2014)

Detecting Cancer Gene Networks Characterized by Recurrent Genomic Alterations in a Population
por: Efroni, Sol, et al.
Publicado: (2011)

Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer
por: Cohen, Helit, et al.
Publicado: (2014)

Visual barcodes for clonal-multiplexing of live microscopy-based assays
por: Kaufman, Tom, et al.
Publicado: (2022)

MHC-IIB Filament Assembly and Cellular Localization Are Governed by the Rod Net Charge
por: Rosenberg, Michael, et al.
Publicado: (2008)

Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria
por: Livyatan, Ilana, et al.
Publicado: (2020)

Resistance to paclitaxel is associated with a variant of the gene BCL2 in multiple tumor types
por: Ben-Hamo, Rotem, et al.
Publicado: (2019)

Tumor PD-L1 expression and molecular profiling are not associated with immune checkpoint inhibitor-induced thyroid dysfunction in advanced NSCLC patients
por: Horesh, Adi, et al.
Publicado: (2023)

Astrocyte‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity
por: Michalovicz, Lindsay T., et al.
Publicado: (2019)

A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy
por: Golan, Shay, et al.
Publicado: (2023)

High SEPT9_i1 Protein Expression Is Associated with High-Grade Prostate Cancers
por: Gilad, Roni, et al.
Publicado: (2015)

Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting
por: Stossel, Chani, et al.
Publicado: (2023)

Systemic control of plant regeneration and wound repair
por: Omary, Moutasem, et al.
Publicado: (2022)

Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
por: Abramowitz, Julia, et al.
Publicado: (2017)

MON-LB008 PD-L1 Expression in Normal Endocrine Tissues
por: Pollack, Rena, et al.
Publicado: (2019)

The Immune System Computes the State of the Body: Crowd Wisdom, Machine Learning, and Immune Cell Reference Repertoires Help Manage Inflammation
por: Cohen, Irun R., et al.
Publicado: (2019)

Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer
por: Gavert, Nancy, et al.
Publicado: (2010)

Standing on the shoulders of microbes: How cancer biologists are expanding their view of hard‐to‐kill persister cells
por: Oren, Yaara
Publicado: (2022)

The prevalence of iron deficiency anemia among African asylum seeking children residing in Tel Aviv
por: Koren, Gideon, et al.
Publicado: (2019)

Emergent Dynamics of Thymocyte Development and Lineage Determination
por: Efroni, Sol, et al.
Publicado: (2007)

Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects
por: Boesch, Maximilian, et al.
Publicado: (2022)

Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development
por: Shilo, Asaf, et al.
Publicado: (2014)

Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma
por: Hirshoren, Nir, et al.
Publicado: (2014)

Framework for identifying drug repurposing candidates from observational healthcare data
por: Ozery-Flato, Michal, et al.
Publicado: (2020)

Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions
por: Narunsky-Haziza, Lian, et al.
Publicado: (2022)

Identification of Key Processes Underlying Cancer Phenotypes Using Biologic Pathway Analysis
por: Efroni, Sol, et al.
Publicado: (2007)

De novo transcriptome assembly databases for the central nervous system of the medicinal leech
por: Hibsh, Dror, et al.
Publicado: (2015)

β-TrCP Inhibition Reduces Prostate Cancer Cell Growth via Upregulation of the Aryl Hydrocarbon Receptor
por: Gluschnaider, Udi, et al.
Publicado: (2010)

The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice
por: Bitton-Worms, Keren, et al.
Publicado: (2010)

Trimodal therapy in T2‐4aN0M0 bladder cancer––How to select the best candidate?
por: Gofrit, Ofer N., et al.
Publicado: (2020)

A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel
por: Bida, Or, et al.
Publicado: (2015)

Quantification of read species behavior within whole genome sequencing of cancer genomes for the stratification and visualization of genomic variation
por: Hibsh, Dror, et al.
Publicado: (2016)

A modeling algorithm for exploring the architecture and construction of bird nests
por: Jessel, Hadass R., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_u6144suaiubi9j30p96tliv12r