Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation

The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on si...

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Detalles Bibliográficos
Autores principales: Conte, Mattia, Fiorillo, Luca, Bianco, Simona, Chiariello, Andrea M., Esposito, Andrea, Nicodemi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335158/
https://www.ncbi.nlm.nih.gov/pubmed/32620890
http://dx.doi.org/10.1038/s41467-020-17141-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335158/
https://www.ncbi.nlm.nih.gov/pubmed/32620890
http://dx.doi.org/10.1038/s41467-020-17141-4

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