Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex

The sodium-leak channel NALCN forms a subthreshold sodium conductance that controls the resting membrane potentials of neurons. The auxiliary subunits of the channel and their functions in mammals are largely unknown. In this study, we demonstrate that two large proteins UNC80 and UNC79 are subunits...

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Detalles Bibliográficos
Autores principales: Wie, Jinhong, Bharthur, Apoorva, Wolfgang, Morgan, Narayanan, Vinodh, Ramsey, Keri, Aranda, Kimberly, Zhang, Qi, Zhou, Yandong, Ren, Dejian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335163/
https://www.ncbi.nlm.nih.gov/pubmed/32620897
http://dx.doi.org/10.1038/s41467-020-17105-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335163/
https://www.ncbi.nlm.nih.gov/pubmed/32620897
http://dx.doi.org/10.1038/s41467-020-17105-8

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