Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress

ER stress and apoptosis contribute to the loss of pancreatic β-cells under pro-diabetic conditions of glucolipotoxicity. Although activation of canonical intrinsic apoptosis is known to require pro-apoptotic Bcl-2 family proteins Bax and Bak, their individual and combined involvement in glucolipotox...

Descripción completa

Detalles Bibliográficos
Autores principales: White, Sarah A., Zhang, Lisa S., Pasula, Daniel J., Yang, Yu Hsuan Carol, Luciani, Dan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335194/
https://www.ncbi.nlm.nih.gov/pubmed/32620813
http://dx.doi.org/10.1038/s41598-020-67755-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335194/
https://www.ncbi.nlm.nih.gov/pubmed/32620813
http://dx.doi.org/10.1038/s41598-020-67755-3

Ejemplares similares