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Alternative transcripts in variant interpretation: the potential for missed diagnoses and misdiagnoses
PURPOSE: Guidelines by professional organizations for assessing variant pathogenicity include the recommendation to utilize biologically relevant transcripts, however there is variability in transcript selection by laboratories. METHODS: We describe three patients whose genomic results were incorrec...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335342/ https://www.ncbi.nlm.nih.gov/pubmed/32366967 http://dx.doi.org/10.1038/s41436-020-0781-x |