Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells

Chk1 kinase is downstream of the ATR kinase in the sensing of improper replication. Previous cell culture studies have demonstrated that Chk1 is essential for replication. Indeed, Chk1 inhibitors are efficacious against tumors with high-level replication stress such as Myc-induced lymphoma cells. Tr...

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Detalles Bibliográficos
Autores principales: Muralidharan, Somsundar V, Nilsson, Lisa M, Lindberg, Mattias F, Nilsson, Jonas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335382/
https://www.ncbi.nlm.nih.gov/pubmed/32571801
http://dx.doi.org/10.26508/lsa.202000671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335382/
https://www.ncbi.nlm.nih.gov/pubmed/32571801
http://dx.doi.org/10.26508/lsa.202000671

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