Cargando…

Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells

Chk1 kinase is downstream of the ATR kinase in the sensing of improper replication. Previous cell culture studies have demonstrated that Chk1 is essential for replication. Indeed, Chk1 inhibitors are efficacious against tumors with high-level replication stress such as Myc-induced lymphoma cells. Tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muralidharan, Somsundar V, Nilsson, Lisa M, Lindberg, Mattias F, Nilsson, Jonas A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335382/ https://www.ncbi.nlm.nih.gov/pubmed/32571801 http://dx.doi.org/10.26508/lsa.202000671

Ejemplares similares

BET bromodomain inhibitors synergize with ATR inhibitors in melanoma
por: Veppil Muralidharan, Somsundar, et al.
Publicado: (2017)

BET bromodomain inhibitors synergize with ATR inhibitors in melanoma
por: Muralidharan, Somsundar Veppil, et al.
Publicado: (2017)

Chk-mate on resistance to kinase inhibitors
por: Shapiro, Paul
Publicado: (2018)

CHK2 is essential for spindle assembly and DNA repair during the first cleavage of mouse embryos
por: Li, Xiao-Han, et al.
Publicado: (2020)

The expression of diacylglycerol kinase theta during the organogenesis of mouse embryos
por: Ueda, Shuji, et al.
Publicado: (2013)

A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos
por: Bliman, David, et al.
Publicado: (2015)

Aurora kinase A is essential for meiosis in mouse oocytes
por: Blengini, Cecilia S., et al.
Publicado: (2021)

CHK2 kinase in the DNA damage response and beyond
por: Zannini, Laura, et al.
Publicado: (2014)

Chk2 Regulates Cell Cycle Progression during Mouse Oocyte Maturation and Early Embryo Development
por: Dai, Xiao-Xin, et al.
Publicado: (2014)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis
por: Mikawa, Takumi, et al.
Publicado: (2020)

Differential Involvement of Kinase Activity of Ca(2+)/Calmodulin-Dependent Protein Kinase IIα in Hippocampus- and Amygdala-Dependent Memory Revealed by Kinase-Dead Knock-In Mouse
por: Yamagata, Yoko, et al.
Publicado: (2018)

High-Content Screening of Eukaryotic Kinase Inhibitors Identify CHK2 Inhibitor Activity Against Mycobacterium tuberculosis
por: Shapira, Tirosh, et al.
Publicado: (2020)

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine
por: Advani, Gahana, et al.
Publicado: (2017)

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model
por: Jespersen, Henrik, et al.
Publicado: (2017)

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos
por: Ju, Jia‐Qian, et al.
Publicado: (2020)

AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival
por: Ta, Huy Q, et al.
Publicado: (2020)

Characterisation of a K390R ITK Kinase Dead Transgenic Mouse – Implications for ITK as a Therapeutic Target
por: Deakin, Angela, et al.
Publicado: (2014)

NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development
por: Schmitz-Rohmer, Debora, et al.
Publicado: (2015)

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
por: Blasius, Melanie, et al.
Publicado: (2011)

Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity
por: Guo, Xin, et al.
Publicado: (2010)

CK1δ Kinase Activity Is Modulated by Chk1-Mediated Phosphorylation
por: Bischof, Joachim, et al.
Publicado: (2013)

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2
por: Advani, Sunil J., et al.
Publicado: (2015)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
por: Sanjiv, Kumar, et al.
Publicado: (2015)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
por: Sanjiv, Kumar, et al.
Publicado: (2016)

Decoding kinase-adverse event associations for small molecule kinase inhibitors
por: Gong, Xiajing, et al.
Publicado: (2022)

The kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress
por: Coulton, Naomi, et al.
Publicado: (2017)

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview
por: Lindberg, Mattias F., et al.
Publicado: (2021)

MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells
por: Bridges, Kathleen A., et al.
Publicado: (2016)

CHK1‐CDC25A‐CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos
por: Knoblochova, Lucie, et al.
Publicado: (2023)

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
por: Weygant, Nathaniel, et al.
Publicado: (2014)

Neural Crest Cell Survival Is Dependent on Rho Kinase and Is Required for Development of the Mid Face in Mouse Embryos
por: Phillips, Helen M., et al.
Publicado: (2012)

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
por: Yamamoto, Kenta, et al.
Publicado: (2016)

Selected arylsulphonyl pyrazole derivatives as potential Chk1 kinase ligands—computational investigations
por: Czaja, Kornelia, et al.
Publicado: (2020)

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
por: Day, Matthew, et al.
Publicado: (2021)

EMG1 is essential for mouse pre-implantation embryo development
por: Wu, Xiaoli, et al.
Publicado: (2010)

Downsizing Treatment with Tyrosine Kinase Inhibitors in Patients with Advanced Gastrointestinal Stromal Tumors Improved Resectability
por: Sjölund, Katarina, et al.
Publicado: (2010)

Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing
por: Bhadury, J, et al.
Publicado: (2013)

Zygotic G2/M Cell Cycle Arrest Induced by ATM/Chk1 Activation and DNA Repair in Mouse Embryos Fertilized with Hydrogen Peroxide-Treated Epididymal Mouse Sperm
por: Wang, Bin, et al.
Publicado: (2013)

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography
por: Matijssen, Cornelis, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mj66ihqit5jt2nsr9ccsq9emcf