Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability

Herein, we report novel macromolecular prodrugs (MPDs) of flurbiprofen (FLB) onto a cellulose ether, hydroxypropylcellulose (HPC). The FLB was activated with a powerful acylation reagent carbonyldiimadazole (CDI) in N,N′ dimethylacetamide (DMAc) solvent at room temperature. Imidazolide of FLB genera...

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Detalles Bibliográficos
Autores principales: Hussain, Muhammad Ajaz, Shad, Iqra, Malik, Iram, Amjad, Fasiha, Kausar, Tehreem, Kamran, Sher, Muhammad, Tahir, Muhammad Nawaz, Ullah, Nisar, Ashraf, Muhammad, Bukhari, Syed Nasir Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335720/
https://www.ncbi.nlm.nih.gov/pubmed/32647489
http://dx.doi.org/10.1016/j.jsps.2020.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335720/
https://www.ncbi.nlm.nih.gov/pubmed/32647489
http://dx.doi.org/10.1016/j.jsps.2020.06.009

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