HIV-Resistant and HIV-Specific CAR-Modified CD4(+) T Cells Mitigate HIV Disease Progression and Confer CD4(+) T Cell Help In Vivo

HIV infection preferentially depletes HIV-specific CD4(+) T cells, thereby impairing antiviral immunity. In this study, we explored the therapeutic utility of adoptively transferred CD4(+) T cells expressing an HIV-specific chimeric antigen receptor (CAR(4)) to restore CD4(+) T cell function to the...

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Detalles Bibliográficos
Autores principales: Maldini, Colby R., Gayout, Kevin, Leibman, Rachel S., Dopkin, Derrick L., Mills, Joshua P., Shan, Xiaochuan, Glover, Joshua A., Riley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335752/
https://www.ncbi.nlm.nih.gov/pubmed/32454027
http://dx.doi.org/10.1016/j.ymthe.2020.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335752/
https://www.ncbi.nlm.nih.gov/pubmed/32454027
http://dx.doi.org/10.1016/j.ymthe.2020.05.012

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