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Experimental and theoretical study on structure-tautomerism among edaravone, isoxazolone, and their heterocycles derivatives as antioxidants

Edaravone is a heterocyclic pyrazolone compound. It has pronounced effect against free radicals, however renal and hepatic disorders have been reported. Isoxazolones are considered bioisosteric analogues of pyrazolones and may have comparable properties. Thus, we investigated the structural and elec...

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Detalles Bibliográficos
Autores principales: Queiroz, Auriekson N., Martins, Camila C., Santos, Kelton L.B., Carvalho, Ederson S., Owiti, Alex O., Oliveira, Karen R.M., Herculano, Anderson M., da Silva, Albérico B.F., Borges, Rosivaldo S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335820/
https://www.ncbi.nlm.nih.gov/pubmed/32647483
http://dx.doi.org/10.1016/j.jsps.2020.06.001
Descripción
Sumario:Edaravone is a heterocyclic pyrazolone compound. It has pronounced effect against free radicals, however renal and hepatic disorders have been reported. Isoxazolones are considered bioisosteric analogues of pyrazolones and may have comparable properties. Thus, we investigated the structural and electronic influences for edaravone, isoxazolone, and their tautomers on antioxidant process. Structure and tautomerism study among edaravone, isoxazolone and their heterocycles derivatives were related to antioxidant mechanisms by using the hybrid DFT method B3LYP with the basis sets 6-31++G(2d,2p). The C—H tautomer was the most stable and energetically favored among them. Intramolecular N—H—N hydrogen bonds and polar medium were responsible for the low energy differences among all possible tautomers. N—H tautomers in both systems proved to be better antioxidant by SET (single electron transfer), while O—H tautomers were better antioxidant on HAT (homolytic hydrogen atom transfer) mechanism. Theoretical calculation showed that edaravone is more potent than phenylisoxazolone, however, both has similar antioxidant scavenging on experimental DPPH. The carbonyliminic system played a very important role in the antioxidant activity for both studied classes.