Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies

BACKGROUND: Voclosporin, a more potent derivative of cyclosporine, has been studied extensively in patients with immunologic disorders such as psoriasis, organ transplantation, uvetitis and lupus nephritis. Although better tolerated and safer than cyclosporine, voclosporin is inferior to cyclosporin...

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Detalles Bibliográficos
Autores principales: Li, Yan, Palmisano, Maria, Sun, Duxin, Zhou, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335848/
https://www.ncbi.nlm.nih.gov/pubmed/32669879
http://dx.doi.org/10.2147/CPAA.S255789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335848/
https://www.ncbi.nlm.nih.gov/pubmed/32669879
http://dx.doi.org/10.2147/CPAA.S255789

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