Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents

Purpose: In this study, a series of piperazin-2-one derivatives were prepared through bioisosteric substitution of the imidazole ring of L-778,123 (imidazole-containing FTase inhibitor) and rearrangement of groups based on the tipifarnib structure. Final compounds were evaluated for their cytotoxic...

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Detalles Bibliográficos
Autores principales: Ghasemi, Saeed, Sharifi, Simin, Shahbazi Mojarrad, Javid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335995/
https://www.ncbi.nlm.nih.gov/pubmed/32665901
http://dx.doi.org/10.34172/apb.2020.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335995/
https://www.ncbi.nlm.nih.gov/pubmed/32665901
http://dx.doi.org/10.34172/apb.2020.051

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