Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration

Upregulation of Brf1 (TFIIB-related factor 1) and Pol III gene (RNA polymerase III-dependent gene, such as tRNAs and 5S rRNA) activities is associated with cell transformation and tumor development. Alcohol intake causes liver injury, such as steatosis, inflammation, fibrosis, and cirrhosis, which e...

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Detalles Bibliográficos
Autores principales: Lin, Mingen, Huang, Chenghao, Ren, Wenfeng, Chen, Jun, Xia, Ningshao, Zhong, Shuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336232/
https://www.ncbi.nlm.nih.gov/pubmed/32685086
http://dx.doi.org/10.1155/2020/2067959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336232/
https://www.ncbi.nlm.nih.gov/pubmed/32685086
http://dx.doi.org/10.1155/2020/2067959

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