HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Herpes simplex virus (HSV) is the main cause of viral encephalitis in the Western world, and the type I interferon (IFN) system is important for antiviral control in the brain. Here, we have compared Ifnb induction in mixed murine brain cell cultures by a panel of HSV1 mutants, each devoid of one me...

Descripción completa

Detalles Bibliográficos
Autores principales: Bodda, Chiranjeevi, Reinert, Line S., Fruhwürth, Stefanie, Richardo, Timmy, Sun, Chenglong, Zhang, Bao-cun, Kalamvoki, Maria, Pohlmann, Anja, Mogensen, Trine H., Bergström, Petra, Agholme, Lotta, O’Hare, Peter, Sodeik, Beate, Gyrd-Hansen, Mads, Zetterberg, Henrik, Paludan, Søren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336311/
https://www.ncbi.nlm.nih.gov/pubmed/32383759
http://dx.doi.org/10.1084/jem.20191422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336311/
https://www.ncbi.nlm.nih.gov/pubmed/32383759
http://dx.doi.org/10.1084/jem.20191422

Ejemplares similares