Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel

GLIC is a bacterial homologue of the pentameric ligand-gated ion channels (pLGICs) that mediate the fast chemical neurotransmission of nerve signalling in eukaryotes. Because the activation and allosteric modulation features are conserved among prokaryotic and eukaryotic pLGICs, GLIC is commonly use...

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Detalles Bibliográficos
Autores principales: Fourati, Zaineb, Sauguet, Ludovic, Delarue, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336382/
https://www.ncbi.nlm.nih.gov/pubmed/32627739
http://dx.doi.org/10.1107/S205979832000772X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336382/
https://www.ncbi.nlm.nih.gov/pubmed/32627739
http://dx.doi.org/10.1107/S205979832000772X

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