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TNF-α promotes the malignant transformation of intestinal stem cells through the NF-κB and Wnt/β-catenin signaling pathways

Cancer stem cells are responsible for tumorigenesis, progression, recurrence and metastasis. Intestinal stem cells (ISCs) are regarded as the origin of intestinal neoplasia. Inflammation also serves an important role in intestinal neoplasia. To explore the molecular mechanisms underlying the inflamm...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaopeng, Ma, Lu, Dai, Lu, Zuo, Di, Li, Xin, Zhu, Hongli, Xu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336517/
https://www.ncbi.nlm.nih.gov/pubmed/32627006
http://dx.doi.org/10.3892/or.2020.7631