Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by inhibition of Arginase-1. We have characterized t...

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Detalles Bibliográficos
Autores principales: Grobben, Yvonne, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Tabak, Werner W.A., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337048/
https://www.ncbi.nlm.nih.gov/pubmed/32647818
http://dx.doi.org/10.1016/j.yjsbx.2019.100014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337048/
https://www.ncbi.nlm.nih.gov/pubmed/32647818
http://dx.doi.org/10.1016/j.yjsbx.2019.100014

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