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Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158
Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by inhibition of Arginase-1. We have characterized t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337048/ https://www.ncbi.nlm.nih.gov/pubmed/32647818 http://dx.doi.org/10.1016/j.yjsbx.2019.100014 |