Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP(3)

P-Rex family Rho guanine-nucleotide exchange factors are important regulators of cell motility through their activation of a subset of small GTPases. Both P-Rex1 and P-Rex2 have also been implicated in the progression of certain cancers, including breast cancer and melanoma. Although these molecules...

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Detalles Bibliográficos
Autores principales: Cash, Jennifer N., Sharma, Prateek V., Tesmer, John J.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337056/
https://www.ncbi.nlm.nih.gov/pubmed/34958187
http://dx.doi.org/10.1016/j.yjsbx.2018.100001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337056/
https://www.ncbi.nlm.nih.gov/pubmed/34958187
http://dx.doi.org/10.1016/j.yjsbx.2018.100001

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