Cargando…

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

Programmed death ligand 1 (PD-L1) has been recently shown to be a major obstacle to antiviral immunity by binding to its receptor programmed death 1 (PD-1) on specific IFN-γ producing T cells in chronic hepatitis B. Currently, IFN-α is widely used to treat hepatitis B virus (HBV) infection, but its...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, LanLan, Hou, Junwei, Xu, Yuxiu, Qin, Lijuan, Liu, Weiwei, Zhang, Han, Li, Yang, Chen, Mi, Deng, Mengmeng, Zhao, Bao, Hu, Jun, Zheng, Huaguo, Li, Changfei, Meng, Songdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337294/ https://www.ncbi.nlm.nih.gov/pubmed/32628668 http://dx.doi.org/10.1371/journal.pone.0228302

Ejemplares similares

Role of STAT1 in the resistance of HBV to IFN-α
por: Xu, Bingfa, et al.
Publicado: (2021)

Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS
por: Yoyen-Ermis, Digdem, et al.
Publicado: (2019)

IFN-γ surmounts PD-L1/PD1 inhibition to CAR-T cell therapy by upregulating ICAM-1 on tumor cells
por: Dong, E, et al.
Publicado: (2021)

Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
por: Li, Xin, et al.
Publicado: (2018)

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination
por: Zhang, Ying, et al.
Publicado: (2018)

Increased HBV Coinfection and Decreased IFN-γ-Producing HBV-Specific CD8+ T Cell Numbers During HIV Disease Progression
por: Zhu, Zhiqiang, et al.
Publicado: (2022)

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
por: Xu, Yuxiu, et al.
Publicado: (2021)

IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1 signaling in EBV-positive gastric carcinoma
por: Moon, Ji Wook, et al.
Publicado: (2017)

Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells
por: Arai, Yohei, et al.
Publicado: (2017)

IFN-γ: A Crucial Player in the Fight Against HBV Infection?
por: Hillaire, Marine Laure Bettina, et al.
Publicado: (2023)

Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway
por: Xue, Weili, et al.
Publicado: (2019)

Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade
por: Vackova, Julie, et al.
Publicado: (2020)

CD137 ligand feedback upregulates PD‐L1 expression on lung cancer via T cell production of IFN‐γ
por: Wang, Helin, et al.
Publicado: (2019)

Activation of IFN-γ/STAT/IRF-1 in Hepatic Responses to Klebsiella pneumoniae Infection
por: Lin, Yi-Chun, et al.
Publicado: (2013)

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
por: Qian, Jiawen, et al.
Publicado: (2018)

IL-11 prevents IFN-γ-induced hepatocyte death through selective downregulation of IFN-γ/STAT1 signaling and ROS scavenging
por: Miyawaki, Akimitsu, et al.
Publicado: (2019)

IFN-γ Induces PD-L1 Expression in Primed Human Basophils
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2022)

PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and predicts a poor survival in colorectal cancer
por: Zhao, Tiancheng, et al.
Publicado: (2020)

LAG-3 expression in microglia regulated by IFN-γ/STAT1 pathway and metalloproteases
por: Morisaki, Yuta, et al.
Publicado: (2023)

IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB
por: GAO, QIYUE, et al.
Publicado: (2016)

Dipyrithione inhibits IFN-γ-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells
por: Han, Cui, et al.
Publicado: (2010)

The Interaction of the IFNγ/JAK/STAT1 and JAK/STAT3 Signalling Pathways in EGFR-Mutated Lung Adenocarcinoma Cells
por: Han, Yaguang, et al.
Publicado: (2022)

IFN-γ induces PD-L1 through p38/JNK/ERK signaling pathways and counteracts the tumor promoting effect mediated by PD-L1 in Glioblastoma
por: Jia, Huafang, et al.
Publicado: (2022)

Increase of cells expressing PD‐1 and PD‐L1 and enhancement of IFN‐γ production via PD‐1/PD‐L1 blockade in bovine mycoplasmosis
por: Goto, Shinya, et al.
Publicado: (2017)

Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response
por: Liu, Weiwei, et al.
Publicado: (2016)

IFN-γ induces apoptosis in human melanocytes by activating the JAK1/STAT1 signaling pathway
por: Su, Qianya, et al.
Publicado: (2020)

GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway
por: Rong, Dawei, et al.
Publicado: (2023)

17β‐estradiol ameliorates age‐associated loss of fibroblast function by attenuating IFN‐γ/STAT1‐dependent miR‐7 upregulation
por: Midgley, Adam C., et al.
Publicado: (2016)

Association of IFN-γ gene polymorphism and levels in HBV related disease chronicity in India
por: Saxena, Roli, et al.
Publicado: (2012)

Active Components with Inhibitory Activities on IFN-γ/STAT1 and IL-6/STAT3 Signaling Pathways from Caulis Trachelospermi
por: Liu, Xiao-Ting, et al.
Publicado: (2014)

Upregulation of PD-L1 Expression by Prostaglandin E(2) and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection
por: Goto, Shinya, et al.
Publicado: (2020)

Campylobacter concisus upregulates PD-L1 mRNA expression in IFN-γ sensitized intestinal epithelial cells and induces cell death in esophageal epithelial cells
por: Lee, Seul A, et al.
Publicado: (2021)

Upregulation of Circulating PD-L1/PD-1 Is Associated with Poor Post-Cryoablation Prognosis in Patients with HBV-Related Hepatocellular Carcinoma
por: Zeng, Zhen, et al.
Publicado: (2011)

IFN-γ–STAT1–iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity
por: Yang, Shu-Han, et al.
Publicado: (2017)

IFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD-1 Therapy in Colorectal Cancer: An in vitro Study
por: Yuan, Wenli, et al.
Publicado: (2021)

PD-1(+) IFN-γ(+) subset of CD8(+) T cell in circulation predicts response to anti–PD-1 therapy in NSCLC
por: Chen, Wenxiu, et al.
Publicado: (2023)

MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFNγ/STAT1 signaling
por: Jiang, Lei, et al.
Publicado: (2019)

PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment
por: Flies, Andrew S., et al.
Publicado: (2016)

CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells
por: Xiong, Jing, et al.
Publicado: (2022)

Synergistic effect of IFN-γ and IL-1β on PD-L1 expression in hepatocellular carcinoma
por: Numata, Yasunao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gpmeu6sp476cjkfgg9mkulp1ib