ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

The autophagy-initiating human ULK complex consists of the kinase ULK1/2, FIP200, ATG13, and ATG101. Hydrogen-deuterium exchange mass spectrometry was used to map their mutual interactions. The N-terminal 640 residues (NTD) of FIP200 interact with the C-terminal IDR of ATG13. Mutations in these regi...

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Detalles Bibliográficos
Autores principales: Shi, Xiaoshan, Yokom, Adam L., Wang, Chunxin, Young, Lindsey N., Youle, Richard J., Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337493/
https://www.ncbi.nlm.nih.gov/pubmed/32516362
http://dx.doi.org/10.1083/jcb.201911047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337493/
https://www.ncbi.nlm.nih.gov/pubmed/32516362
http://dx.doi.org/10.1083/jcb.201911047

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