Structural insights into G domain dimerization and pathogenic mutation of OPA1

The fusion of mammalian inner mitochondrial membranes (IMMs) is mediated by dynamin-like GTPase OPA1. Mutations in human OPA1 cause optic atrophy, but the molecular basis for membrane fusion and pathogenesis is not clear. Here, we determined the crystal structure of the minimal GTPase domain (MGD) o...

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Detalles Bibliográficos
Autores principales: Yu, Caiting, Zhao, Jinghua, Yan, Liming, Qi, Yuanbo, Guo, Xiangyang, Lou, Zhiyong, Hu, Junjie, Rao, Zihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337494/
https://www.ncbi.nlm.nih.gov/pubmed/32379273
http://dx.doi.org/10.1083/jcb.201907098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337494/
https://www.ncbi.nlm.nih.gov/pubmed/32379273
http://dx.doi.org/10.1083/jcb.201907098

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