A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

Autophagy degrades cytoplasmic cargo by its delivery to lysosomes within double membrane autophagosomes. Synthesis of the phosphoinositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3 proteins to phagophore membranes by the ATG12–...

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Detalles Bibliográficos
Autores principales: Fracchiolla, Dorotea, Chang, Chunmei, Hurley, James H., Martens, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337497/
https://www.ncbi.nlm.nih.gov/pubmed/32437499
http://dx.doi.org/10.1083/jcb.201912098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337497/
https://www.ncbi.nlm.nih.gov/pubmed/32437499
http://dx.doi.org/10.1083/jcb.201912098

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