UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD

Accumulation of unfolded antibody chains in the ER triggers ER stress that may lead to reduced productivity in therapeutic antibody manufacturing processes. We identified UBR4 and UBR5 as ubiquitin E3 ligases involved in HC ER-associated degradation. Knockdown of UBR4 and UBR5 resulted in intracellu...

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Detalles Bibliográficos
Autores principales: Tang, Danming, Sandoval, Wendy, Lam, Cynthia, Haley, Benjamin, Liu, Peter, Xue, Di, Roy, Deepankar, Patapoff, Tom, Louie, Salina, Snedecor, Brad, Misaghi, Shahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337499/
https://www.ncbi.nlm.nih.gov/pubmed/32558906
http://dx.doi.org/10.1083/jcb.201908087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337499/
https://www.ncbi.nlm.nih.gov/pubmed/32558906
http://dx.doi.org/10.1083/jcb.201908087

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