A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity

Mechanisms coupling the atypical PKC (aPKC) kinase activity to its subcellular localization are essential for cell polarization. Unlike other members of the PKC family, aPKC has no well-defined plasma membrane (PM) or calcium binding domains, leading to the assumption that its subcellular localizati...

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Detalles Bibliográficos
Autores principales: Dong, Wei, Lu, Juan, Zhang, Xuejing, Wu, Yan, Lettieri, Kaela, Hammond, Gerald R., Hong, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337507/
https://www.ncbi.nlm.nih.gov/pubmed/32580209
http://dx.doi.org/10.1083/jcb.201903031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337507/
https://www.ncbi.nlm.nih.gov/pubmed/32580209
http://dx.doi.org/10.1083/jcb.201903031

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