CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes

DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG) helicase. Although the CMG architecture has been elucidated, its mechanism of DNA unwinding and replisome interactions remain poorly understood. Here we report the cryoEM structure at 3.3 Å of human CMG bound to fork DN...

Descripción completa

Detalles Bibliográficos
Autores principales: Rzechorzek, Neil J, Hardwick, Steven W, Jatikusumo, Vincentius A, Chirgadze, Dimitri Y, Pellegrini, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337937/
https://www.ncbi.nlm.nih.gov/pubmed/32453425
http://dx.doi.org/10.1093/nar/gkaa429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337937/
https://www.ncbi.nlm.nih.gov/pubmed/32453425
http://dx.doi.org/10.1093/nar/gkaa429

Ejemplares similares