Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation

The accuracy in pairing tRNAs with correct amino acids by aminoacyl-tRNA synthetases (aaRSs) dictates the fidelity of translation. To ensure fidelity, multiple aaRSs developed editing functions that remove a wrong amino acid from tRNA before it reaches the ribosome. However, no specific mechanism wi...

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Detalles Bibliográficos
Autores principales: Chen, Meirong, Kuhle, Bernhard, Diedrich, Jolene, Liu, Ze, Moresco, James J, Yates III, John R, Pan, Tao, Yang, Xiang-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337962/
https://www.ncbi.nlm.nih.gov/pubmed/32484512
http://dx.doi.org/10.1093/nar/gkaa469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337962/
https://www.ncbi.nlm.nih.gov/pubmed/32484512
http://dx.doi.org/10.1093/nar/gkaa469

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