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Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core
Self-templating assemblies of the human prion protein are clinically associated with transmissible spongiform encephalopathies. Here we present the cryo-EM structure of a denaturant- and protease-resistant fibril formed in vitro spontaneously by a 9.7kDa unglycosylated fragment of the human prion pr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338044/ https://www.ncbi.nlm.nih.gov/pubmed/32284600 http://dx.doi.org/10.1038/s41594-020-0403-y |