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Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

Self-templating assemblies of the human prion protein are clinically associated with transmissible spongiform encephalopathies. Here we present the cryo-EM structure of a denaturant- and protease-resistant fibril formed in vitro spontaneously by a 9.7kDa unglycosylated fragment of the human prion pr...

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Detalles Bibliográficos
Autores principales:	Glynn, Calina, Sawaya, Michael R., Ge, Peng, Gallagher-Jones, Marcus, Short, Connor W., Bowman, Ronquiajah, Apostol, Marcin, Zhou, Z. Hong, Eisenberg, David, Rodriguez, Jose A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338044/ https://www.ncbi.nlm.nih.gov/pubmed/32284600 http://dx.doi.org/10.1038/s41594-020-0403-y

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