Microglia TREM2(R47H) Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

To study the mechanisms by which the p.R47H variant of the microglia gene and Alzheimer’s disease (AD) risk factor TREM2 increases dementia risk, we created Trem2(R47H) KI rats. Trem2(R47H) rats were engineered to produce human Aβ to define human-Aβ-dependent and -independent pathogenic mechanisms t...

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Detalles Bibliográficos
Autores principales: Ren, Siqiang, Yao, Wen, Tambini, Marc D, Yin, Tao, Norris, Kelly A, D'Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338048/
https://www.ncbi.nlm.nih.gov/pubmed/32579116
http://dx.doi.org/10.7554/eLife.57513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338048/
https://www.ncbi.nlm.nih.gov/pubmed/32579116
http://dx.doi.org/10.7554/eLife.57513

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