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Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression. Here, we report the cryo-electron microscopy (cryo-EM) structure...

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Detalles Bibliográficos
Autores principales: Farnung, Lucas, Ochmann, Moritz, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338049/
https://www.ncbi.nlm.nih.gov/pubmed/32543371
http://dx.doi.org/10.7554/eLife.56178