AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival

We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR)...

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Detalles Bibliográficos
Autores principales: Ta, Huy Q, Dworak, Natalia, Ivey, Melissa L, Roller, Devin G, Gioeli, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338052/
https://www.ncbi.nlm.nih.gov/pubmed/32579110
http://dx.doi.org/10.7554/eLife.51378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338052/
https://www.ncbi.nlm.nih.gov/pubmed/32579110
http://dx.doi.org/10.7554/eLife.51378

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