Cargando…

AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival

We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ta, Huy Q, Dworak, Natalia, Ivey, Melissa L, Roller, Devin G, Gioeli, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338052/ https://www.ncbi.nlm.nih.gov/pubmed/32579110 http://dx.doi.org/10.7554/eLife.51378

Ejemplares similares

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity
por: Guo, Xin, et al.
Publicado: (2010)

The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor
por: Liang, Xiaobing, et al.
Publicado: (2011)

γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments
por: Rawlinson, Rebecca, et al.
Publicado: (2014)

CHK2 kinase in the DNA damage response and beyond
por: Zannini, Laura, et al.
Publicado: (2014)

Chk-mate on resistance to kinase inhibitors
por: Shapiro, Paul
Publicado: (2018)

CK1δ Kinase Activity Is Modulated by Chk1-Mediated Phosphorylation
por: Bischof, Joachim, et al.
Publicado: (2013)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

Effects of the mycorrhizal fungus Ceratobasidium sp. AR2 on growth and flavonoid accumulation in Anoectochilus roxburghii
por: Zhang, Ying, et al.
Publicado: (2020)

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation via derepression of Chk1 catalytic activity
por: Walker, M, et al.
Publicado: (2009)

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells
por: Zhang, Yanchun, et al.
Publicado: (2022)

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
por: Manic, Gwenola, et al.
Publicado: (2015)

Analysis of CHK2 in vulval neoplasia
por: Reddy, A, et al.
Publicado: (2002)

Regulation of Chk1
por: Tapia-Alveal, Claudia, et al.
Publicado: (2009)

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation
por: Badie, Sophie, et al.
Publicado: (2009)

CHK1 phosphorylates PRIMPOL to promote replication stress tolerance
por: Mehta, Kavi P. M., et al.
Publicado: (2022)

Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1
por: Meng, Zheng, et al.
Publicado: (2011)

Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
por: Black, Elizabeth M., et al.
Publicado: (2022)

SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation
por: Zhang, Wenyu, et al.
Publicado: (2019)

CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation
por: Guo, Ran, et al.
Publicado: (2022)

Regulation, targets and functions of CHK
por: Zhu, Shudong, et al.
Publicado: (2022)

Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation
por: Yu, Zi-Jian, et al.
Publicado: (2017)

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2
por: Advani, Sunil J., et al.
Publicado: (2015)

Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity
por: Massey, Andrew J.
Publicado: (2016)

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis
por: Mikawa, Takumi, et al.
Publicado: (2020)

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
por: Di Benedetto, Anna, et al.
Publicado: (2017)

Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
por: Qu, Meng, et al.
Publicado: (2012)

Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma
por: Hu, Guanghui, et al.
Publicado: (2020)

Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine
por: Duong, Hong-Quan, et al.
Publicado: (2013)

Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia
por: Rorà, Andrea Ghelli Luserna Di, et al.
Publicado: (2016)

Chk1 suppressed cell death
por: Meuth, Mark
Publicado: (2010)

Checkmate to CHK1 in T-cell ALL?
por: Sarmento, Leonor M., et al.
Publicado: (2015)

Editorial: Regulation and dysfunction of CSK and CHK
por: Zhu, Shudong, et al.
Publicado: (2023)

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
por: Koudelková, Lenka, et al.
Publicado: (2023)

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb
por: Mayfield, Joshua E, et al.
Publicado: (2019)

CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage
por: Magni, Martina, et al.
Publicado: (2015)

Absence of Germline CHK2 Mutations in Familial Gastric Cancer
por: Kimura, Kenji, et al.
Publicado: (2000)

An ATM–Chk2–INCENP pathway activates the abscission checkpoint
por: Petsalaki, Eleni, et al.
Publicado: (2020)

Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb
por: Huang, Fang, et al.
Publicado: (2021)

Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2
por: Zhang, Liangyu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_08art0gmudqvr189rp4n6avokg