The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

Determining how microtubules (MTs) are nucleated is essential for understanding how the cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex (γ-TuRC) has been identified, precisely how γ-TuRC nucleates a MT remains poorly understood. Here, we developed a single molecule assay to di...

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Detalles Bibliográficos
Autores principales: Thawani, Akanksha, Rale, Michael J, Coudray, Nicolas, Bhabha, Gira, Stone, Howard A, Shaevitz, Joshua W, Petry, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338055/
https://www.ncbi.nlm.nih.gov/pubmed/32538784
http://dx.doi.org/10.7554/eLife.54253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338055/
https://www.ncbi.nlm.nih.gov/pubmed/32538784
http://dx.doi.org/10.7554/eLife.54253

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