Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice

AIMS: Lipotoxic cardiomyopathy in diabetic and obese patients typically encompasses increased cardiac fatty acid (FA) uptake eventually surpassing the mitochondrial oxidative capacity. Lowering FA utilization via inhibition of lipolysis represents a strategy to counteract the development of lipotoxi...

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Detalles Bibliográficos
Autores principales: Kolleritsch, Stephanie, Kien, Benedikt, Schoiswohl, Gabriele, Diwoky, Clemens, Schreiber, Renate, Heier, Christoph, Maresch, Lisa Katharina, Schweiger, Martina, Eichmann, Thomas O., Stryeck, Sarah, Krenn, Petra, Tomin, Tamara, Schittmayer, Matthias, Kolb, Dagmar, Rülicke, Thomas, Hoefler, Gerald, Wolinski, Heimo, Madl, Tobias, Birner-Gruenberger, Ruth, Haemmerle, Guenter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338219/
https://www.ncbi.nlm.nih.gov/pubmed/31166588
http://dx.doi.org/10.1093/cvr/cvz119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338219/
https://www.ncbi.nlm.nih.gov/pubmed/31166588
http://dx.doi.org/10.1093/cvr/cvz119

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