Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo

We investigated the anti-angiogenic and pro-apoptotic effects of robustaflavone (RF), a naturally occurring biflavonoid, on human umbilical vein endothelial cells (HUVECs). RF inhibited HUVEC proliferation and showed cytotoxicity that inhibited HUVEC viability. RF-induced apoptosis was characterized...

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Detalles Bibliográficos
Autores principales: Sim, Woo Kyung, Park, Jong-Hwa, Kim, Ki-Young, Chung, In Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338547/
https://www.ncbi.nlm.nih.gov/pubmed/32632123
http://dx.doi.org/10.1038/s41598-020-67993-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338547/
https://www.ncbi.nlm.nih.gov/pubmed/32632123
http://dx.doi.org/10.1038/s41598-020-67993-5

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