A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine

The murine intestinal nematode Heligmosomoides polygyrus releases the H. polygyrus Alarmin Release Inhibitor (HpARI) - a protein which binds to IL-33 and to DNA, effectively tethering the cytokine in the nucleus of necrotic cells. Previous work showed that a non-natural truncation consisting of the...

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Detalles Bibliográficos
Autores principales: Chauché, Caroline, Vacca, Francesco, Chia, Shin Li, Richards, Josh, Gregory, William F., Ogunkanbi, Adefunke, Wear, Martin, McSorley, Henry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338556/
https://www.ncbi.nlm.nih.gov/pubmed/32695116
http://dx.doi.org/10.3389/fimmu.2020.01363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338556/
https://www.ncbi.nlm.nih.gov/pubmed/32695116
http://dx.doi.org/10.3389/fimmu.2020.01363

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