ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients

Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of t...

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Detalles Bibliográficos
Autores principales: Riera, Pau, Artigas-Baleri, Alícia, Salazar, Juliana, Sebio, Ana, Virgili, Anna C., Arranz, María Jesús, Páez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338599/
https://www.ncbi.nlm.nih.gov/pubmed/32695000
http://dx.doi.org/10.3389/fphar.2020.00973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338599/
https://www.ncbi.nlm.nih.gov/pubmed/32695000
http://dx.doi.org/10.3389/fphar.2020.00973

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