CGG Repeat Expansion, and Elevated Fmr1 Transcription and Mitochondrial Copy Number in a New Fragile X PM Mouse Embryonic Stem Cell Model

The Fragile-X related disorders (FXDs) are Repeat Expansion Diseases (REDs) that result from expansion of a CGG-repeat tract located at the 5′ end of the FMR1 gene. While expansion affects transmission risk and can also affect disease risk and severity, the underlying molecular mechanism responsible...

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Detalles Bibliográficos
Autores principales: Gazy, Inbal, Miller, Carson J., Kim, Geum-Yi, Usdin, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338602/
https://www.ncbi.nlm.nih.gov/pubmed/32695777
http://dx.doi.org/10.3389/fcell.2020.00482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338602/
https://www.ncbi.nlm.nih.gov/pubmed/32695777
http://dx.doi.org/10.3389/fcell.2020.00482

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