Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also activates TLR4 signaling, but it is unknown if heme interacts with MD-2. Therefore, we examined MD-2 for a potential heme activation site. Heme-agaro...

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Detalles Bibliográficos
Autores principales: Belcher, John D., Zhang, Ping, Nguyen, Julia, Kiser, Zachary M., Nath, Karl A., Hu, Jianjun, Trent, John O., Vercellotti, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338675/
https://www.ncbi.nlm.nih.gov/pubmed/32695117
http://dx.doi.org/10.3389/fimmu.2020.01370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338675/
https://www.ncbi.nlm.nih.gov/pubmed/32695117
http://dx.doi.org/10.3389/fimmu.2020.01370

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