Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade

Human-ether-a-go-go-related channel (hERG1) is the pore-forming domain of the delayed rectifier K(+) channel in the heart which underlies the I(Kr) current. The channel has been extensively studied due to its propensity to bind chemically diverse group of drugs. The subsequent hERG1 block can lead t...

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Detalles Bibliográficos
Autores principales: Kudaibergenova, Meruyert, Guo, Jiqing, Khan, Hanif M., Zahid, Farhan, Lees-Miller, James, Noskov, Sergei Yu., Duff, Henry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338687/
https://www.ncbi.nlm.nih.gov/pubmed/32694995
http://dx.doi.org/10.3389/fphar.2020.00914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338687/
https://www.ncbi.nlm.nih.gov/pubmed/32694995
http://dx.doi.org/10.3389/fphar.2020.00914

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