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Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade
Human-ether-a-go-go-related channel (hERG1) is the pore-forming domain of the delayed rectifier K(+) channel in the heart which underlies the I(Kr) current. The channel has been extensively studied due to its propensity to bind chemically diverse group of drugs. The subsequent hERG1 block can lead t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338687/ https://www.ncbi.nlm.nih.gov/pubmed/32694995 http://dx.doi.org/10.3389/fphar.2020.00914 |