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Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells

BACKGROUND: Drug resistance is frequently found in estrogen receptor–positive (ER(+)) breast cancer patients during and after prolonged tamoxifen treatment. Although tamoxifen rechallenge has been proposed for treating recurrent breast tumors, the clinical benefit of this treatment is still controve...

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Detalles Bibliográficos
Autores principales: Chang, Yung-Chieh, Cheung, Chun Hei Antonio, Kuo, Yao-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338790/
https://www.ncbi.nlm.nih.gov/pubmed/32695778
http://dx.doi.org/10.3389/fcell.2020.00485