FBXL4 deficiency increases mitochondrial removal by autophagy

Pathogenic variants in FBXL4 cause a severe encephalopathic syndrome associated with mtDNA depletion and deficient oxidative phosphorylation. To gain further insight into the enigmatic pathophysiology caused by FBXL4 deficiency, we generated homozygous Fbxl4 knockout mice and found that they display...

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Detalles Bibliográficos
Autores principales: Alsina, David, Lytovchenko, Oleksandr, Schab, Aleksandra, Atanassov, Ilian, Schober, Florian A, Jiang, Min, Koolmeister, Camilla, Wedell, Anna, Taylor, Robert W, Wredenberg, Anna, Larsson, Nils‐Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338799/
https://www.ncbi.nlm.nih.gov/pubmed/32525278
http://dx.doi.org/10.15252/emmm.201911659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338799/
https://www.ncbi.nlm.nih.gov/pubmed/32525278
http://dx.doi.org/10.15252/emmm.201911659

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