T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria

Hybrid Th1/Tfh cells (IFN-γ(+)IL-21(+)CXCR5(+)) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ(+) T cells control parasitemia, whereas antibody and IL-21(+)Bcl6(+) T cells effect final clearance, suggesting an evolutionary driver for the hybrid popu...

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Detalles Bibliográficos
Autores principales: Carpio, Victor H., Aussenac, Florentin, Puebla-Clark, Lucinda, Wilson, Kyle D., Villarino, Alejandro V., Dent, Alexander L., Stephens, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339051/
https://www.ncbi.nlm.nih.gov/pubmed/32634740
http://dx.doi.org/10.1016/j.isci.2020.101310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339051/
https://www.ncbi.nlm.nih.gov/pubmed/32634740
http://dx.doi.org/10.1016/j.isci.2020.101310

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