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T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria
Hybrid Th1/Tfh cells (IFN-γ(+)IL-21(+)CXCR5(+)) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ(+) T cells control parasitemia, whereas antibody and IL-21(+)Bcl6(+) T cells effect final clearance, suggesting an evolutionary driver for the hybrid popu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339051/ https://www.ncbi.nlm.nih.gov/pubmed/32634740 http://dx.doi.org/10.1016/j.isci.2020.101310 |