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Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer

Numb is known as a cell fate determinant as it identifies the direction of cell differentiation via asymmetrical partitioning during mitosis. It is considered as a tumour suppressor, and a frequent loss of Numb expression in breast cancer is noted. Numb forms a tri‐complex with p53 and E3 ubiquitin...

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Detalles Bibliográficos
Autores principales: Xian, Jie, Cheng, Yu, Qin, Xue, Cao, Yijia, Luo, Yetao, Cao, Youde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339219/
https://www.ncbi.nlm.nih.gov/pubmed/32501652
http://dx.doi.org/10.1111/jcmm.15366