Cargando…
Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer
Numb is known as a cell fate determinant as it identifies the direction of cell differentiation via asymmetrical partitioning during mitosis. It is considered as a tumour suppressor, and a frequent loss of Numb expression in breast cancer is noted. Numb forms a tri‐complex with p53 and E3 ubiquitin...
Autores principales: | Xian, Jie, Cheng, Yu, Qin, Xue, Cao, Yijia, Luo, Yetao, Cao, Youde |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339219/ https://www.ncbi.nlm.nih.gov/pubmed/32501652 http://dx.doi.org/10.1111/jcmm.15366 |
Ejemplares similares
-
Prognostic Biomarker NUMB Is Inhibited by Breast Cancer Cell Exosomes to Promote Breast Cancer Progression
por: Qin, Xue, et al.
Publicado: (2022) -
Positive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer
por: Zeng, Yan, et al.
Publicado: (2019) -
A role for Numb in p53 stabilization
por: Carter, Stephanie, et al.
Publicado: (2008) -
NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
por: Zhang, Jianchao, et al.
Publicado: (2016) -
Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018)