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Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas

Radiotherapy is the cornerstone of treatment of high-grade gliomas (HGGs). It eradicates tumor cells by inducing oxidative stress and subsequent DNA damage. Unfortunately, almost all HGGs recur locally within several months secondary to radioresistance with intricate molecular mechanisms. Therefore,...

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Detalles Bibliográficos
Autores principales: Shen, Han, Cook, Kristina, Gee, Harriet E., Hau, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339573/
https://www.ncbi.nlm.nih.gov/pubmed/32631383
http://dx.doi.org/10.1186/s13046-020-01639-2